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Vaginal clear cell carcinoma

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Primary vaginal carcinoma , although being a rare overall, is still the 5 th commonest gynecological malignancy. A primary vaginal carcinoma is defined as a neoplasm that arises solely from the vagina with no involvement of the external os superiorly or the vulva inferiorly, the importance of this definition lying in the fact that the most of malignancies involving the vagina are due to invasion from nearby tumors and the different clinical approaches in the treatment of cervical carcinoma and vulval carcinoma. The typical age at presentation is at around the 6 th to 7 th decades of life. Lesions characteristically arise from the posterior wall of the upper third of the vagina. The common patterns of disease are:.
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Primary clear cell carcinoma of the vagina that is not related to in utero diethylstilbestrol use

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Clear Cell Carcinoma of Cervix

Professional Reference articles are designed for health professionals to use. You may find one of our health articles more useful. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Vaginal cancer is usually a squamous cell carcinoma involving the posterior wall of the upper third of the vagina. It may directly invade the bladder or rectum. Lesions may be ulcerative or exophytic.
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Clear cell carcinoma of the vagina

Diethylstilbestrol DES is a synthetic form of the female hormone estrogen. It was prescribed to pregnant women between and to prevent miscarriage, premature labor, and related complications of pregnancy 1. The use of DES declined after studies in the s showed that it was not effective in preventing these problems. In , researchers linked prenatal before birth DES exposure to a type of cancer of the cervix and vagina called clear cell adenocarcinoma in a small group of women 2.
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Background: We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol DES exposure. Case presentation: In this case, the patient was a Chinese woman with a history of two decades of intermittent vaginal pain, sexual intercourse pain and vaginal contact bleeding. On September 1, , when the patient was 39 years old, a vaginal biopsy revealed vaginal adenosis.
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