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Gene expression analysis in breast cancer - DORAS
Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. There are many ongoing trials exploring the use of PARP inhibitors in other breast cancer settings or using alternative treatment strategies. These include use of talazoparib and niraparib in the metastatic setting, use of olaparib in the adjuvant setting, use of talazoparib in the neoadjuvant setting, identifying patients responsive to PARP inhibitor treatment including use of the RAD51 assay to identify potential responders to veliparib and combination strategies with chemotherapy and immunotherapies as the combination partner. Higher response rates in the subgroup analysis deserve further research. A number of trials are investigating PARP inhibitors in the metastatic breast cancer setting. Several of these now specify that patients must carry an identified mutation in an HRR -related gene before entering the study.
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